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Mammalian cell biology at present is split between two camps: one of which values precision in molecular perturbation and analysis with focus on experimental well-defined 2D settings and the other which values 3D tissue context most and accepts a diminished molecular tool kit in exchange for increased physiologic relevance. A third strategy has been to exploit the power of genetically tractable and optically transparent model systems to elucidate fundamental molecular pathways and cellular processes in (for example) Drosophila and then seek to validate the resulting concepts in mammalian systems. This Workshop aims to bridge the gaps between these experimental strategies and reach “multi-scale” molecular understanding of how cells build organs during development and corrupt their structure and function during disease processes. As key themes, we will focus on the areas of cell adhesion, cell migration, and tumor cell biology and integrate 2D and 3D culture technology for enabling mechanistic cell biology within tissues, including organoids and alternate approaches to 3D cell culture.

Specific goals and themes:

1. Adoption of novel techniques (3D culture, microdevices, imaging, biosensors) into cell-cell adhesion and migration reseach

2. Novel tools for gene manipulation and molecular analysis in 3D culture and in vivo.

3. Combinatorial approaches to probe molecular and physical cell functions in tissue environments

4. Translate lessons from basic cell biology to complex models of morphogenesis and cancer

5. Bridge between models and results by computational biology / bioinformatics

This workshop will bring together experts in molecular cell biology, biophysics, developmental biologists, microscopists, engineers and experts in optical sensor technology to highlight cutting-edge in vitro and in vivo strategies to address mechanisms of complex cell functions.

This proposed conference aims to provide insight into functional cell biology and basic mechanisms of disease research, develop new directions for investigation and forge new collaborations and interactions across multiple disciplines. Sufficient time for discussion and informal interactions will be provided.

The Company of Biologists’ Workshops only take place three times per year, on topics that are driving forward the progress of life sciences and biomedical research. The meetings are small and intensive, taking place over 3 days with 20 invited participants, all of whom we ask to make a presentation, and a further 10 chosen from submitted applications (students and postdocs as well as junior PIs). A condition of attendance is that you are present for the full meeting, from Sunday lunchtime through to Wednesday lunchtime.

3D multi-channel imaging and movies of cancer cells in living mice show how streams of melanoma cells (green) invade skin tissue. The cells are guided by structures such as muscle fibres (orange), nerve fibres (blue), collagen (grey) and blood vessels (red). Image courtesy of Bettina Weigelin and Peter Friedl, Radboudumc, The Netherlands.